Publications — Gronert Lab

Key Publications

Leedom, A.J., Sullivan, A.B., Dong, B., Lau, D. and Gronert, K. Endogenous LXA4 Circuits are Determinants of Pathological Angiogenesis in Response to Chronic Injury. Am J Pathol 2010; 176: 74-84. PMID: 20008149.
Wang S.B., Hu K.M., Seamon K.J., Mani V., Chen Y., Gronert K. Estrogen Negatively Regulates Epithelial Wound Healing and Protective Lipid Mediator Circuits in the Cornea. FASEB J 2012; 26 (4):1506-16. PMID: 22186873.
Gao, Y., Min, K., Zhang, Y., Su, J., Greenwood, M., and Gronert, K. Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease. Journal of Immunology 2015; 195, 3086-3099. PMID: 26324767.
Gao, Y., Su, J., Zhang, Y., Chan, A., Sin, J.H., Wu, D., Min, K., Gronert, K. Dietary DHA Amplifies LXA4 Circuits in Tissues and Lymph Node PMN and is Protective in Immune-Driven Dry Eye Disease. Mucosal Immunol 2018; 11(6):1674-1683. PMID: 30104626.

Livne-Bar, I., Wei, J., Liu, H.H., Alqawlaq, S., Won, G.J., Tuccitto, A., Gronert, K.¹, Flanagan, J.G.¹, and Sivak, J.M.¹. Astrocyte-derived Lipoxins A4 and B4 Promote Neuroprotection from Acute and Chronic Injury. J Clin Invest 2017; 127, 4403-4414; PMID: 29106385. (¹co-senior authors)
Wei, J., Mattapallil, M.J., Horai, R., Jittayasothorn, Y., Modi, A.P., Sen, H.N., Gronert, K.¹, Caspi, R.R.¹. A Novel Role for Lipoxin A4 in Driving a Lymph Node-Eye Axis that Controls Autoimmunity to the Neuroretina. Elife 2020 2:9 e51102; PMID: 32118582 (¹co-corresponding authors)
Karnam S, Maurya S, Ng E, Choudhary A, Thobani A, Flanagan JG, Gronert K. Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension. Acta Neuropathol Commun. 2024 Apr 12;12(1):58. PMID: 38610040.
Maurya S, Lin M, Karnam S, Singh T, Kumar M, Ward E, Sivak J, Flanagan JG, Gronert K. Regulation of disease-associated microglia in the optic nerve by lipoxin B4 and ocular hypertension. Mol Neurodegener. 2024 Nov 20;19(1):86. PMID: 39568070.

von Moltke, J., Trinidad, N.J., Moayeri, M., Kintzer, A.F., Wang, S.B., van Rooijen, N., Brown, C.R., Kranytz, B.A., Leppla, S.H., Gronert, K¹ and Vance, R.E.¹. Rapid Induction of Lipid Mediators is a Novel Effector Function of the Inflammasome In Vivo. Nature 2012; 490 (7418):107-111; PMID: 23045615. (¹co-corresponding authors)
Rauch, I., Deets, K.A., Ji, D.X., von Moltke, J., Tenthorey, J.L., Lee, A.Y., Philip, N.H., Ayres, J.S., Brodsky, I.E., Gronert, K., Vance, R.E. NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. Immunity 2017; 18, 46(4): 649-659. PMID: 28410991.

Wei, J., and Gronert, K. The Role of Pro-Resolving Lipid Mediators in Ocular Diseases. Molecular Aspects of Medicine 2017; 58, 37-43. PMID: 32360792.
Wei, J., and Gronert, K. Eicosanoid and Specialized Proresolving Mediator Regulation of Lymphoid Cells, Trends in Biochemical Sciences (TIBS) 2019; 44 (3):214-225. PMID: 30477730.
Flitter, B.A., Fang, X., Matthay, M.A., Gronert, K. The Potential of Lipid Mediator Networks as Ocular Surface Therapeutics and Biomarkers. Ocular Surface 2021; 19:104-114. PMID: 32360792.