Publications — Gronert Lab

Key Publications

Leedom, A.J., Sullivan, A.B., Dong, B., Lau, D. and Gronert, K. Endogenous LXA4 Circuits are Determinants of Pathological Angiogenesis in Response to Chronic Injury. Am J Pathol 2010; 176: 74-84. PMID: 20008149.
Wang S.B., Hu K.M., Seamon K.J., Mani V., Chen Y., Gronert K. Estrogen Negatively Regulates Epithelial Wound Healing and Protective Lipid Mediator Circuits in the Cornea. FASEB J 2012; 26 (4):1506-16. PMID: 22186873.
Gao, Y., Min, K., Zhang, Y., Su, J., Greenwood, M., and Gronert, K. Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease. Journal of Immunology 2015; 195, 3086-3099. PMID: 26324767.
Gao, Y., Su, J., Zhang, Y., Chan, A., Sin, J.H., Wu, D., Min, K., Gronert, K. Dietary DHA Amplifies LXA4 Circuits in Tissues and Lymph Node PMN and is Protective in Immune-Driven Dry Eye Disease. Mucosal Immunol 2018; 11(6):1674-1683. PMID: 30104626.

Livne-Bar, I., Wei, J., Liu, H.H., Alqawlaq, S., Won, G.J., Tuccitto, A., Gronert, K.¹, Flanagan, J.G.¹, and Sivak, J.M.¹. Astrocyte-derived Lipoxins A4 and B4 Promote Neuroprotection from Acute and Chronic Injury. J Clin Invest 2017; 127, 4403-4414; PMID: 29106385. (¹co-senior authors)
Wei, J., Mattapallil, M.J., Horai, R., Jittayasothorn, Y., Modi, A.P., Sen, H.N., Gronert, K.¹, Caspi, R.R.¹. A Novel Role for Lipoxin A4 in Driving a Lymph Node-Eye Axis that Controls Autoimmunity to the Neuroretina. Elife 2020 2:9 e51102; PMID: 32118582 (¹co-corresponding authors)

von Moltke, J., Trinidad, N.J., Moayeri, M., Kintzer, A.F., Wang, S.B., van Rooijen, N., Brown, C.R., Kranytz, B.A., Leppla, S.H., Gronert, K¹ and Vance, R.E.¹. Rapid Induction of Lipid Mediators is a Novel Effector Function of the Inflammasome In Vivo. Nature 2012; 490 (7418):107-111; PMID: 23045615. (¹co-corresponding authors)
Rauch, I., Deets, K.A., Ji, D.X., von Moltke, J., Tenthorey, J.L., Lee, A.Y., Philip, N.H., Ayres, J.S., Brodsky, I.E., Gronert, K., Vance, R.E. NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. Immunity 2017; 18, 46(4): 649-659. PMID: 28410991.

Wei, J., and Gronert, K. The Role of Pro-Resolving Lipid Mediators in Ocular Diseases. Molecular Aspects of Medicine 2017; 58, 37-43. PMID: 32360792.
Wei, J., and Gronert, K. Eicosanoid and Specialized Proresolving Mediator Regulation of Lymphoid Cells, Trends in Biochemical Sciences (TIBS) 2019; 44 (3):214-225. PMID: 30477730.
Flitter, B.A., Fang, X., Matthay, M.A., Gronert, K. The Potential of Lipid Mediator Networks as Ocular Surface Therapeutics and Biomarkers. Ocular Surface 2021; 19:104-114. PMID: 32360792.